PF3D7_0509300

Genome location: Pf3D7_05_v3:388,184..389,809(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.09	0.95
Trophozoite	expressed	0.21	0.87
Schizont	expressed	0.04	0.98
Gametocyte	expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0509300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.213 | MFS: -2.688 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1108900)

Relative Growth Rate: 1.02 ± 0.14
Confidence: 5.34

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1108900)

Modification: Disrupted | RMgm-2968

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9E3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533094

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	3	6	1	5
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	singleton
synonymous	0	0	0
disruptive	6	8	2
missense	0	0	0

PlasmoDB Total SNPs: 93

Non-coding: 88 | Synonymous: 2 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 115 | Molecular Weight (kDa): 13.505

UniProt ID(s): A0A5K1K9E3

PDB ID(s): None

Isoelectric Point: 10.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108