PF3D7_0509700

Genome location: Pf3D7_05_v3:405,961..407,897(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.04	0.98
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.88	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0509700

Resistome Missense Mutations: K143Q

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -2.914 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1109300)

Relative Growth Rate: 1.03 ± 0.14
Confidence: 5.27

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1109300)

Modification: Disrupted | RMgm-2972

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I407

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533394

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	12	9	20
disruptive	6	44	31	77
missense	3	39	29	74

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	27	12	30
disruptive	13	92	46	88
missense	8	79	43	66

PlasmoDB Total SNPs: 146

Non-coding: 123 | Synonymous: 18 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 395 | Molecular Weight (kDa): 46.417

UniProt ID(s): Q8I407

PDB ID(s): None

Isoelectric Point: 4.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A