PF3D7_0510000

Genome location: Pf3D7_05_v3:417,823..422,380(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0042393	histone binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.24	0.86
Schizont	not expressed	0.25	0.85
Gametocyte	possibly expressed	0.64	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0510000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.587 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1109600)

Relative Growth Rate: 0.98 ± 0.16
Confidence: 5.07

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1109600)

Modification: Disrupted | RMgm-2975

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I404

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532967

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	25	16	24
disruptive	9	72	45	103
missense	7	70	43	96

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	41	22	47
disruptive	25	162	93	167
missense	15	136	76	132

PlasmoDB Total SNPs: 271

Non-coding: 183 | Synonymous: 57 | Nonsynonymous: 31 | Stop Codon: 0

Protein Information

Protein Length: 782 | Molecular Weight (kDa): 94.17

UniProt ID(s): Q8I404

PDB ID(s): None

Isoelectric Point: 5.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A