PF3D7_0510100

Genome location: Pf3D7_05_v3:421,563..431,426(-)

Genome classification: Core

Function and Localization

Product Description: KH domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003723	RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.36	0.84
Trophozoite	expressed	1.90	0.26
Schizont	expressed	2.29	0.19
Gametocyte	expressed	1.06	0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0510100

Resistome Missense Mutations: Y144S, N1042H

Resistome Compounds with Missense Mutations: MMV688533, Suloctidil

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.369 | MFS: -2.606 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1109700)

Relative Growth Rate: 0.02 ± 0.04
Confidence: 7.88

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I403

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_120995

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	28	100	63	128
disruptive	112	383	224	549
missense	66	280	181	445

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	45	203	99	172
disruptive	216	820	414	825
missense	116	621	323	544

PlasmoDB Total SNPs: 469

Non-coding: 111 | Synonymous: 188 | Nonsynonymous: 170 | Stop Codon: 0

Protein Information

Protein Length: 2535 | Molecular Weight (kDa): 297.572

UniProt ID(s): Q8I403

PDB ID(s): None

Isoelectric Point: 6.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR031121	KH domain containing protein RIK/BLOM7
InterPro	IPR036612	K Homology domain, type 1 superfamily
PFam	N/A	N/A
Superfamily	SSF54791	K Homology domain, type 1 superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108