About Gene List

PF3D7_0510300 (SIP)

Genome location: Pf3D7_05_v3:440,724..442,007(-)

Genome classification: Core

Function and Localization

Product Description: stripes inner membrane complex protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0071944 cell periphery
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.00 1.00
Trophozoite not expressed 0.00 1.00
Schizont not expressed 0.00 1.00
Gametocyte expressed 0.06 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0510300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.177 | MFS: -2.919 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1109900)

  • Relative Growth Rate: 1.05 ± 0.16
  • Confidence: 5.09

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1109900)

Modification: Disrupted | RMgm-2978

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I401

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130938

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 9 6 14
disruptive 1 4 2 22
missense 1 4 2 19

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 24 9 15
disruptive 1 10 15 32
missense 1 7 14 28

PlasmoDB Total SNPs: 22

Non-coding: 18 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 246 | Molecular Weight (kDa): 28.35

UniProt ID(s): Q8I401

PDB ID(s): None

Isoelectric Point: 9

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
24887026 Identification of TgCBAP, a novel cytoskeletal protein that localizes to threedistinct subcompartments of the Toxoplasma gondii pellicle. Tilley LD, Krishnamurthy S, Westwood NJ, Ward GE 10.1371/journal.pone.0098492
25088010 Identification and characterization of Toxoplasma SIP, a conserved apicomplexancytoskeleton protein involved in maintaining the shape, motility and virulence ofthe parasite. Lentini G, Kong-Hap M, ..., Lebrun M 10.1111/cmi.12337