PF3D7_0510400

Genome location: Pf3D7_05_v3:443,533..445,913(+)

Genome classification: Core

Function and Localization

Product Description: PDCD2 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.24	0.88
Trophozoite	possibly expressed	0.23	0.87
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.09	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0510400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.151 | MFS: -2.816 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I400

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103161

Most Similar Human Ortholog: Q9BRP1

TM-align score: 0.60 | RMSD: 3.79

Seq Identity: 0.19 | Length: 249 / 439

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000126249	programmed cell death 2 like

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	11	9	15
disruptive	12	34	21	55
missense	12	30	21	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	26	15	21
disruptive	17	82	44	93
missense	14	67	41	49

PlasmoDB Total SNPs: 74

Non-coding: 47 | Synonymous: 13 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 439 | Molecular Weight (kDa): 51.917

UniProt ID(s): Q8I400

PDB ID(s): None

Isoelectric Point: 5.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007320	Programmed cell death protein 2, C-terminal
PFam	PF04194	Programmed cell death protein 2, C-terminal
Superfamily	N/A	N/A