PF3D7_0510800

Genome location: Pf3D7_05_v3:461,017..464,399(+)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	expressed	0.03	0.98
Schizont	expressed	0.01	0.99
Gametocyte	expressed	0.46	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0510800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.996 | MFS: -0.933 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4D3

"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=0.32) with 4GM8 (Global RMSD=2.48)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106030

Most Similar Human Ortholog: H0Y811

TM-align score: 0.87 | RMSD: 1.58

Seq Identity: 0.21 | Length: 233 / 642

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000144451	sperm associated antigen 16

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	21	9	25
disruptive	5	36	16	70
missense	5	30	16	67

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	32	18	26
disruptive	9	72	42	79
missense	8	56	40	69

PlasmoDB Total SNPs: 107

Non-coding: 81 | Synonymous: 22 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 642 | Molecular Weight (kDa): 74.166

UniProt ID(s): C0H4D3

PDB ID(s): None

Isoelectric Point: 6.67

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR020472	G-protein beta WD-40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
Superfamily	SSF50978	WD40-repeat-containing domain superfamily