Product Description: translationally-controlled tumor protein homolog
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0020020 | food vacuole |
| Function | GO:0005509 | calcium ion binding |
| Process | GO:0032715 | negative regulation of interleukin-6 production |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.45 | 0.79 |
| Trophozoite | expressed | 1.01 | 0.48 |
| Schizont | expressed | 0.26 | 0.83 |
| Gametocyte | expressed | 0.43 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0511000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.994 | MFS: 0.283 | #Insertions: 1
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1110500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1110500)
Modification: Disrupted | RMgm-2979
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3Z5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101832
Most Similar Human Ortholog: P13693
TM-align score: 0.82 | RMSD: 1.83
Seq Identity: 0.33 | Length: 150 / 171
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000133112 | tumor protein, translationally-controlled 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 2 | 3 | 2 |
| disruptive | 1 | 2 | 5 | 15 |
| missense | 1 | 2 | 4 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 6 | 2 | 3 |
| disruptive | 1 | 11 | 9 | 22 |
| missense | 1 | 8 | 7 | 16 |
PlasmoDB Total SNPs: 33
Non-coding: 30 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 171 | Molecular Weight (kDa): 19.979
PDB ID(s): 3P3K
Isoelectric Point: 4.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011057 | Mss4-like superfamily |
| InterPro | IPR018103 | Translationally controlled tumour protein, conserved site |
| InterPro | IPR018105 | Translationally controlled tumour protein |
| PFam | PF00838 | Translationally controlled tumour protein |
| Superfamily | SSF51316 | Mss4-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10535309 | The Plasmodium falciparum translationally controlled tumor protein: subcellularlocalization and calcium binding. | Bhisutthibhan J, Philbert MA, ..., Meshnick SR | 10.1016/S0171-9335(99)80052-1 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 25329441 | Plasmodium berghei histamine-releasing factor favours liver-stage development viainhibition of IL-6 production and associates with a severe outcome of disease. | Mathieu C, Demarta-Gatsi C, ..., Mecheri S | 10.1111/cmi.12382 |