Product Description: stearoyl-CoA desaturase
SignalP Peptide: N/A
# Transmembrane Domains: 18
EC Numbers: 1.14.19.1 (Stearoyl-CoA 9-desaturase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Function | GO:0005506 | iron ion binding |
| Function | GO:0004768 | stearoyl-CoA 9-desaturase activity |
| Process | GO:0006633 | fatty acid biosynthetic process |
| Process | GO:0006636 | unsaturated fatty acid biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 1.03 | 0.54 |
| Schizont | expressed | 1.13 | 0.51 |
| Gametocyte | expressed | 0.71 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0511200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.018 | #Insertions: 5
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I0W9
"Best" AlphaFill ligand hit: 3VV (s-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name), Local RMSD=0.60) with 6WF2 (Global RMSD=2.65)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.14.19.1 | stearoyl-CoA 9-desaturase | NADHEDTAHgCl2azideisoxylSAR707MF-152ethanolGSK-993A939572CGX0168CGX0290... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q86SK9 | Stearoyl-CoA desaturase 5 | Homo sapiens | OrthoDB | MLS000087229US10919885, Compound No. 4US10919885, Compound No. 6US10919885, Compound No. 7... |
| P13516 | Acyl-CoA desaturase 1 | Mus musculus | OrthoDB | CHEMBL3394702CHEMBL3394701CHEMBL3394700CHEMBL3394699... |
| O00767 | Stearoyl-CoA desaturase | OrthoDB | US8962837, Sterculic acidUS8962837, 6US8962837, 7US8962837, 8... | |
| P07308 | Acyl-CoA desaturase 1 | OrthoDB | US9102669, 42US9102669, 43US9102669, 44US9102669, 46... |
Ortholog Group (OrthoMCL): OG6_100468
Most Similar Human Ortholog: Q86SK9
TM-align score: 0.84 | RMSD: 2.12
Seq Identity: 0.34 | Length: 292 / 949
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000099194 | stearoyl-CoA desaturase |
| ENSG00000145284 | stearoyl-CoA desaturase 5 |
Protein Length: 949 | Molecular Weight (kDa): 114.073
UniProt ID(s): Q8I0W9
PDB ID(s): None
Isoelectric Point: 9.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR015876 | Acyl-CoA desaturase |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 21 | 17 | 42 |
| disruptive | 6 | 29 | 15 | 56 |
| missense | 5 | 25 | 14 | 46 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 53 | 31 | 50 |
| disruptive | 17 | 72 | 26 | 98 |
| missense | 11 | 52 | 24 | 77 |
PlasmoDB Total SNPs: 101
Non-coding: 69 | Synonymous: 24 | Nonsynonymous: 8 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 19707292 | Oleic acid biosynthesis in Plasmodium falciparum: characterization of thestearoyl-CoA desaturase and investigation as a potential therapeutic target. | Gratraud P, Huws E, ..., Kremer L | 10.1371/journal.pone.0006889 |
| 38419272 | Stearoyl-CoA desaturase regulates organelle biogenesis and hepatic merozoiteformation in Plasmodium berghei | Narwal SK, Mishra A, ..., Mishra S | 10.1111/mmi.15246 |