PF3D7_0511300

Genome location: Pf3D7_05_v3:474,407..478,999(-)

Genome classification: Core

Function and Localization

Product Description: MORN repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020005	symbiont-containing vacuole membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.17	0.92
Trophozoite	possibly expressed	0.65	0.64
Schizont	not expressed	0.12	0.92
Gametocyte	not expressed	0.74	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0511300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.558 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1110800)

Relative Growth Rate: 0.86 ± 0.17
Confidence: 4.89

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1110800)

Modification: Disrupted | RMgm-2981

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Z3

"Best" AlphaFill ligand hit: EST (estradiol, Local RMSD=1.01) with 1AQU (Global RMSD=16.79)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532503

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	37	26	53
disruptive	46	124	62	173
missense	32	96	57	141

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	70	30	85
disruptive	76	254	125	314
missense	43	201	97	224

PlasmoDB Total SNPs: 194

Non-coding: 28 | Synonymous: 107 | Nonsynonymous: 59 | Stop Codon: 0

Protein Information

Protein Length: 1417 | Molecular Weight (kDa): 168.009

UniProt ID(s): Q8I3Z3

PDB ID(s): None

Isoelectric Point: 5.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003409	MORN motif
InterPro	IPR018307	AVL9/DENND6 domain
PFam	PF02493	MORN motif
PFam	PF09794	AVL9/DENND6 domain
Superfamily	SSF82185	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
21498641	Protein targeting to the parasitophorous vacuole membrane of Plasmodiumfalciparum.	Eksi S, Williamson KC	10.1128/EC.00008-11