About Gene List

PF3D7_0511400

Genome location: Pf3D7_05_v3:481,423..482,568(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MNMINIGYLLLVLSFLLLEKTFYG

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.01 0.99
Trophozoite not expressed 0.03 0.98
Schizont not expressed 0.03 0.98
Gametocyte not expressed 0.05 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0511400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.094 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1110900)

Modification: Disrupted | RMgm-2982

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Z2

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=2.50) with 6JWR (Global RMSD=19.52)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533272

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 4 7 15
disruptive 51 39 26 77
missense 41 24 17 56

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 16 11 19
disruptive 60 89 54 110
missense 45 51 42 61

PlasmoDB Total SNPs: 73

Non-coding: 0 | Synonymous: 27 | Nonsynonymous: 46 | Stop Codon: 0

Protein Information

Protein Length: 381 | Molecular Weight (kDa): 45.583

UniProt ID(s): Q8I3Z2

PDB ID(s): None

Isoelectric Point: 4.98

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
22665598 PFE0565w, a Plasmodium falciparum protein expressed in salivary glandsporozoites. Schlarman MS, Roberts RN, ..., Beerntsen BT 10.4269/ajtmh.2012.11-0797
27128092 Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. Swearingen KE, Lindner SE, ..., Sinnis P 10.1371/journal.ppat.1005606