PF3D7_0511600 (ARNP)

Genome location: Pf3D7_05_v3:517,088..518,520(-)

Genome classification: Core

Function and Localization

Product Description: apical rhoptry neck protein

SignalP Peptide: MKKIYFILLILFHLNFMEC

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:1990225	rhoptry neck

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	possibly expressed	0.05	0.97
Schizont	expressed	1.22	0.47
Gametocyte	not expressed	0.04	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0511600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.068 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Z0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532948

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	6	4	13
disruptive	2	18	11	29
missense	1	10	8	21

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	15	6	16
disruptive	8	52	33	78
missense	3	24	19	38

PlasmoDB Total SNPs: 49

Non-coding: 23 | Synonymous: 15 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 208 | Molecular Weight (kDa): 24.731

UniProt ID(s): Q8I3Z0

PDB ID(s): None

Isoelectric Point: 10.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23499754	Identification of novel rhoptry neck protein of Plasmodium falciparum.	Hans N, Singh S, Jain SK, Chauhan VS	10.1016/j.molbiopara.2013.02.007