Product Description: EKC/KEOPS complex subunit CGI121
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000408 | EKC/KEOPS complex |
| Component | GO:0005737 | cytoplasm |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.06 | 0.96 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | not expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0511700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -3.581 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3Y9
"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.82) with 3ENH (Global RMSD=4.56)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103892
Most Similar Human Ortholog: Q9Y3C4
TM-align score: 0.83 | RMSD: 2.38
Seq Identity: 0.25 | Length: 167 / 179
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000144034 | TP53RK binding protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 135
Non-coding: 128 | Synonymous: 3 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 179 | Molecular Weight (kDa): 21.065
UniProt ID(s): Q8I3Y9
PDB ID(s): None
Isoelectric Point: 6.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013926 | CGI121/TPRKB |
| InterPro | IPR036504 | CGI121/TPRKB superfamily |
| PFam | PF08617 | CGI121/TPRKB |
| Superfamily | SSF143870 | CGI121/TPRKB superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 25204654 | Kinase-associated endopeptidase 1 (Kae1) participates in an atypicalribosome-associated complex in the apicoplast of Plasmodium falciparum. | Mallari JP, Oksman A, Vaupel B, Goldberg DE | 10.1074/jbc.M114.586735 |
| 27903914 | Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a coresubunit homologous to yeast Gon7 | Wan LC, Maisonneuve P, ..., Sicheri F | 10.1093/nar/gkw1181 |
| 23945934 | Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of theuniversal t6A tRNA modification | Perrochia L, Guetta D, ..., Basta T | 10.1093/nar/gkt720 |
| 29804714 | Yeast KEOPS complex regulates telomere length independently of its t(6)Amodification function | Liu YY, He MH, ..., Zhou JQ | 10.1016/j.jgg.2018.03.004 |
| 38085018 | Sua5 catalyzing universal t(6)A tRNA modification is responsible for multifaceted functions of the KEOPS complex in Cryptococcus neoformans | Choi Y, Hyeon H, Lee K, Bahn Y-S | 10.1128/msphere.00557-23 |
| 33277478 | A substrate binding model for the KEOPS tRNA modifying complex | Beenstock J, Ona SM, ..., Sicheri F | 10.1038/s41467-020-19990-5 |
| 36416748 | Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidaseactivity | Li QX, Liu JC, He MH, Zhou JQ | 10.1042/BCJ20220290 |
| 25735745 | Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a modelfor the complete yeast KEOPS complex | Zhang W, Collinet B, ..., van Tilbeurgh H | 10.1093/nar/gkv155 |
| 23823807 | The Drosophila EKC/KEOPS complex: roles in protein synthesis homeostasis and animal growth | Rojas-Benitez D, Ibar C, Glavic A | 10.4161/fly.25227 |
| 23620299 | Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation oftRNA using a minimal enzyme system | Wan LC, Mao DY, ..., Sicheri F | 10.1093/nar/gkt322 |
| 22927945 | A genetic investigation of the KEOPS complex in halophilic Archaea | Naor A, Thiaville PC, ..., Gophna U | 10.1371/journal.pone.0043013 |
| 18951093 | Atomic structure of the KEOPS complex: an ancient protein kinase-containingmolecular machine | Mao DY, Neculai D, ..., Sicheri F | 10.1016/j.molcel.2008.10.002 |
| 36377896 | Unraveling the Pathobiological Role of the Fungal KEOPS Complex in Cryptococcusneoformans | Choi Y, Jeong E, ..., Bahn YS | 10.1128/mbio.02944-22 |
| 33681985 | Reciprocal hemizygosity analysis reveals that the Saccharomyces cerevisiae CGI121gene affects lag time duration in synthetic grape must | Li R, Deed RC | 10.1093/g3journal/jkab061 |