Product Description: inositol-3-phosphate synthase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.5.1.4 (Inositol-3-phosphate synthase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0004512 | inositol-3-phosphate synthase activity |
| Process | GO:0006021 | inositol biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.66 | 0.71 |
| Trophozoite | expressed | 1.32 | 0.38 |
| Schizont | expressed | 0.69 | 0.62 |
| Gametocyte | expressed | 0.94 | 0.52 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0511800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.93 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3Y8
"Best" AlphaFill ligand hit: NAI (nadh, Local RMSD=0.55) with 1P1J (Global RMSD=4.60)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.5.1.4 | inositol-3-phosphate synthase | NEMNADHEDTAPCMBNaBH4FeCl2PbCl2cholinelithiumNH4HCO3sorbitolmannitol... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100830
Most Similar Human Ortholog: J3QRY0
TM-align score: 0.88 | RMSD: 1.67
Seq Identity: 0.26 | Length: 145 / 604
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105655 | inositol-3-phosphate synthase 1 |
| ENSG00000105656 | elongation factor for RNA polymerase II |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 9 | 36 |
| disruptive | 0 | 12 | 19 | 56 |
| missense | 0 | 12 | 19 | 50 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 52 | 18 | 29 |
| disruptive | 5 | 50 | 45 | 103 |
| missense | 1 | 44 | 37 | 66 |
PlasmoDB Total SNPs: 84
Non-coding: 68 | Synonymous: 13 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 604 | Molecular Weight (kDa): 69.112
UniProt ID(s): Q8I3Y8
PDB ID(s): None
Isoelectric Point: 7.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002587 | Myo-inositol-1-phosphate synthase |
| InterPro | IPR013021 | Myo-inositol-1-phosphate synthase, GAPDH-like |
| InterPro | IPR036291 | NAD(P)-binding domain superfamily |
| PFam | PF01658 | Myo-inositol-1-phosphate synthase, GAPDH-like |
| PFam | PF07994 | Myo-inositol-1-phosphate synthase |
| Superfamily | SSF51735 | NAD(P)-binding domain superfamily |
| Superfamily | SSF55347 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 24350823 | Plasmodium falciparum is dependent on de novo myo-inositol biosynthesis forassembly of GPI glycolipids and infectivity. | Macrae JI, Lopaticki S, ..., McConville MJ | 10.1111/mmi.12496 |
| 32458684 | Promoter-Library-Based Pathway Optimization for Efficient (2S)-NaringeninProduction from p-Coumaric Acid in Saccharomyces cerevisiae | Gao S, Zhou H, Zhou J, Chen J | 10.1021/acs.jafc.0c01130 |
| 35716778 | Phosphatidic acid species 34:1 mediates expression of the myo-inositol3-phosphate synthase gene INO1 for lipid synthesis in yeast | Gaspar ML, Aregullin MA, ..., Henry SA | 10.1016/j.jbc.2022.102148 |
| 36659814 | Dynamic coalescence of yeast Heat Shock Protein genes bypasses the requirementfor actin | Rubio LS, Gross DS | 10.1093/genetics/iyad006 |
| 36854718 | Adaptive partitioning of a gene locus to the nuclear envelope in Saccharomycescerevisiae is driven by polymer-polymer phase separation | Gonzalez L, Kolbin D, ..., Michnick SW | 10.1038/s41467-023-36391-6 |
| 32211027 | Recruitment of an Activated Gene to the Yeast Nuclear Pore Complex RequiresSumoylation | Saik NO, Park N, ..., Wozniak RW | 10.3389/fgene.2020.00174 |