PF3D7_0511900

Genome location: Pf3D7_05_v3:524,501..527,218(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.18	0.91
Trophozoite	possibly expressed	0.29	0.83
Schizont	possibly expressed	0.04	0.98
Gametocyte	not expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0511900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.191 | MFS: -2.777 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Y7

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=4.48) with 5OXF (Global RMSD=16.22)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532563

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	14	14	29
disruptive	19	73	45	109
missense	13	51	39	79

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	36	20	48
disruptive	46	158	93	191
missense	23	113	68	127

PlasmoDB Total SNPs: 81

Non-coding: 50 | Synonymous: 13 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 730 | Molecular Weight (kDa): 88.158

UniProt ID(s): Q8I3Y7

PDB ID(s): None

Isoelectric Point: 9.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A