Product Description: prefoldin subunit 6
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0016272 | prefoldin complex |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Function | GO:0051087 | chaperone binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0051131 | chaperone-mediated protein complex assembly |
| Process | GO:0006457 | protein folding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.16 | 0.92 |
| Trophozoite | expressed | 0.57 | 0.67 |
| Schizont | expressed | 0.11 | 0.93 |
| Gametocyte | expressed | 0.72 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0512000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.709 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3Y6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102523
Most Similar Human Ortholog: O15212
TM-align score: 0.88 | RMSD: 1.84
Seq Identity: 0.27 | Length: 116 / 119
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000204220 | prefoldin subunit 6 |
| ENSG00000206283 | prefoldin subunit 6 |
| ENSG00000224782 | prefoldin subunit 6 |
| ENSG00000235692 | prefoldin subunit 6 |
| ENSG00000237335 | prefoldin subunit 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 5 | 4 | 8 |
| disruptive | 0 | 2 | 1 | 4 |
| missense | 0 | 2 | 1 | 4 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 9 | 4 | 7 |
| disruptive | 0 | 7 | 4 | 20 |
| missense | 0 | 7 | 1 | 16 |
PlasmoDB Total SNPs: 141
Non-coding: 136 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 119 | Molecular Weight (kDa): 13.667
UniProt ID(s): Q8I3Y6
PDB ID(s): None
Isoelectric Point: 5.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002777 | Prefoldin beta-like |
| PFam | PF01920 | Prefoldin beta-like |
| Superfamily | SSF46579 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 33145997 | Prefoldin subunit 6 of Plasmodium falciparum binds merozoite surface protein-1. | Kumar V, Shoaib R, ..., Singh S | 10.1002/2211-5463.13022 |
| 31376783 | Design, synthesis and biological evaluation of 4-aminoquinoline-guanylthioureaderivatives as antimalarial agents | Bhagat S, Arfeen M, ..., Bharatam PV | 10.1016/j.bioorg.2019.103094 |
| 28577368 | Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads | Jain J, Jain SK, Walker LA, Tekwani BL | 10.1186/s40360-017-0147-4 |
| 30484156 | The Yeast Prefoldin Bud27 | Martinez-Fernandez V, Garrido-Godino AI, Cuevas-Bermudez A, Navarro F | 10.1007/978-3-030-00737-9_8 |