PF3D7_0512100

Genome location: Pf3D7_05_v3:528,729..529,510(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.59	0.66
Schizont	not expressed	0.14	0.91
Gametocyte	possibly expressed	0.53	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0512100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.301 | MFS: -3.471 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Y5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_179329

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	5	3	14
disruptive	4	9	4	12
missense	4	9	4	10

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	10	8	10
disruptive	6	24	10	26
missense	5	19	8	21

PlasmoDB Total SNPs: 49

Non-coding: 44 | Synonymous: 2 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 128 | Molecular Weight (kDa): 15.718

UniProt ID(s): Q8I3Y5

PDB ID(s): None

Isoelectric Point: 10.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A