Product Description: CDK-activating kinase assembly factor MAT1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0005675 | transcription factor TFIIH holo complex |
| Function | GO:0005515 | protein binding |
| Process | GO:0006281 | DNA repair |
| Process | GO:0032147 | activation of protein kinase activity |
| Process | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.22 | 0.89 |
| Trophozoite | possibly expressed | 0.39 | 0.76 |
| Schizont | not expressed | 0.09 | 0.94 |
| Gametocyte | not expressed | 0.19 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0512300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.154 | MFS: -2.78 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1111900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3Y3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103797
Most Similar Human Ortholog: P51948
TM-align score: 0.41 | RMSD: 3.90
Seq Identity: 0.18 | Length: 132 / 260
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000020426 | MNAT1 component of CDK activating kinase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 5 | 8 |
| disruptive | 2 | 10 | 10 | 19 |
| missense | 2 | 9 | 10 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 16 | 7 | 5 |
| disruptive | 5 | 31 | 18 | 60 |
| missense | 2 | 26 | 14 | 37 |
PlasmoDB Total SNPs: 98
Non-coding: 84 | Synonymous: 9 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 260 | Molecular Weight (kDa): 31.307
UniProt ID(s): Q8I3Y3
PDB ID(s): None
Isoelectric Point: 7.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004575 | Cdk-activating kinase assembly factor MAT1/Tfb3 |
| InterPro | IPR015877 | Cdk-activating kinase assembly factor MAT1, centre |
| InterPro | IPR017907 | Zinc finger, RING-type, conserved site |
| InterPro | IPR018957 | Zinc finger, C3HC4 RING-type |
| PFam | PF00097 | Zinc finger, C3HC4 RING-type |
| PFam | PF06391 | Cdk-activating kinase assembly factor MAT1, centre |
| Superfamily | SSF57850 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16737745 | Identification of an effector protein and gain-of-function mutants that activatePfmrk, a malarial cyclin-dependent protein kinase. | Chen Y, Jirage D, ..., Waters NC | 10.1016/j.molbiopara.2006.04.004 |
| 20332005 | The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replicationproteins and co-localize in the nucleus. | Jirage D, Chen Y, ..., Waters NC | https://pubmed.ncbi.nlm.nih.gov/20332005/ |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 38349544 | Ethanolic extract from fruiting bodies of Cordyceps militaris HL8 exhibitscytotoxic activities against cancer cells, skin pathogenic yeasts, andpostharvest pathogen Penicillium digitatum | Vu TX, Tran TB, ..., Tran VT | 10.1007/s00203-024-03833-8 |