PF3D7_0512400

Genome location: Pf3D7_05_v3:536,273..536,977(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.02	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.10	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0512400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.142 | MFS: -3.021 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1112000)

Relative Growth Rate: 1.04 ± 0.11
Confidence: 5.84

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1112000)

Modification: Disrupted | RMgm-2986

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Y2

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=2.46) with 6JWQ (Global RMSD=19.00)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532841

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	5	7
disruptive	10	33	14	26
missense	9	33	13	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	14	7	11
disruptive	19	58	28	51
missense	16	52	25	25

PlasmoDB Total SNPs: 9

Non-coding: 0 | Synonymous: 4 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 234 | Molecular Weight (kDa): 28.519

UniProt ID(s): Q8I3Y2

PDB ID(s): None

Isoelectric Point: 9.9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A