PF3D7_0512500

Genome location: Pf3D7_05_v3:539,571..543,685(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.08	0.96
Trophozoite	expressed	0.46	0.74
Schizont	possibly expressed	0.17	0.88
Gametocyte	possibly expressed	0.49	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0512500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.174 | MFS: -3.29 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3Y1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533228

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	25	12	43
disruptive	11	53	28	96
missense	7	48	26	92

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	46	30	41
disruptive	28	123	73	159
missense	19	99	63	129

PlasmoDB Total SNPs: 158

Non-coding: 117 | Synonymous: 34 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 817 | Molecular Weight (kDa): 99.177

UniProt ID(s): Q8I3Y1

PDB ID(s): None

Isoelectric Point: 9.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A