PF3D7_0512800

Genome location: Pf3D7_05_v3:548,139..553,825(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.32	0.81
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.60	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0512800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.039 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1112500)

Relative Growth Rate: 0.03 ± 0.03
Confidence: 8.11

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3X9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_207076

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	59	35	69
disruptive	52	182	90	244
missense	41	161	86	222

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	115	47	97
disruptive	96	338	162	290
missense	61	293	139	238

PlasmoDB Total SNPs: 205

Non-coding: 49 | Synonymous: 84 | Nonsynonymous: 71 | Stop Codon: 1

Protein Information

Protein Length: 1644 | Molecular Weight (kDa): 198.699

UniProt ID(s): Q8I3X9

PDB ID(s): None

Isoelectric Point: 9.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A