Product Description: AKAP-like protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0016208 | AMP binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0034237 | protein kinase A regulatory subunit binding |
| Process | GO:0010738 | regulation of protein kinase A signaling |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.10 | 0.95 |
| Trophozoite | possibly expressed | 0.57 | 0.67 |
| Schizont | expressed | 0.14 | 0.91 |
| Gametocyte | not expressed | 0.31 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0512900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.999 | MFS: 0.666 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3X8
"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.28) with 2VFK (Global RMSD=2.23)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q7TN79 | A-kinase anchor protein 7 isoform gamma | OrthoMCL BLAST | US9556111, Table 1.17US9556111, Table 1.14US9556111, Table 1.16US9556111, Table 1.18... | |
| Q9P0M2 | A-kinase anchor protein 7 isoform gamma | OrthoMCL BLAST | US9556111, Table 1.14US9556111, Table 1.16US9556111, Table 1.17US9556111, Table 1.18... |
Ortholog Group (OrthoMCL): OG6_106238
Most Similar Human Ortholog: F5GXD1
TM-align score: 0.75 | RMSD: 2.52
Seq Identity: 0.21 | Length: 221 / 265
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000118507 | A-kinase anchoring protein 7 |
Protein Length: 265 | Molecular Weight (kDa): 31.952
UniProt ID(s): Q8I3X8
PDB ID(s): None
Isoelectric Point: 9.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009097 | Cyclic phosphodiesterase |
| InterPro | IPR019510 | Protein kinase A anchor protein, nuclear localisation signal domain |
| PFam | PF10469 | Protein kinase A anchor protein, nuclear localisation signal domain |
| Superfamily | SSF55144 | Cyclic phosphodiesterase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 8 | 3 | 12 |
| disruptive | 2 | 20 | 8 | 51 |
| missense | 2 | 19 | 8 | 48 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 12 | 9 | 17 |
| disruptive | 4 | 44 | 33 | 61 |
| missense | 3 | 38 | 29 | 53 |
PlasmoDB Total SNPs: 15
Non-coding: 1 | Synonymous: 10 | Nonsynonymous: 4 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 27129434 | Characterization of an A-kinase anchoring protein-like suggests an alternativeway of PKA anchoring in Plasmodium falciparum. | Bandje K, Naissant B, ..., Merckx A | 10.1186/s12936-016-1275-9 |