PF3D7_0513000

Genome location: Pf3D7_05_v3:555,264..556,651(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MNFVFIYIVLISFFNKSRC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	expressed	0.15	0.89
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.94	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0513000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -3.279 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1112700)

Relative Growth Rate: 0.95 ± 0.15
Confidence: 5.23

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1112700)

Modification: Disrupted | RMgm-2989

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3X7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_120267

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	12	5	14
disruptive	1	7	8	17
missense	1	7	7	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	23	4	18
disruptive	3	22	12	42
missense	2	17	9	33

PlasmoDB Total SNPs: 45

Non-coding: 40 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 269 | Molecular Weight (kDa): 31.039

UniProt ID(s): Q8I3X7

PDB ID(s): None

Isoelectric Point: 6.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A