About Gene List

PF3D7_0513100

Genome location: Pf3D7_05_v3:556,685..558,060(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.98
Trophozoite not expressed 0.14 0.91
Schizont not expressed 0.42 0.73
Gametocyte expressed 0.41 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0513100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -3.081 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4D5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122905

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 10 7 15
disruptive 1 7 4 14
missense 1 7 4 14

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 24 12 13
disruptive 4 16 10 35
missense 3 12 10 22

PlasmoDB Total SNPs: 92

Non-coding: 81 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 251 | Molecular Weight (kDa): 28.852

UniProt ID(s): C0H4D5

PDB ID(s): None

Isoelectric Point: 5.09

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
29269729 A conserved ankyrin repeat-containing protein regulates conoid stability,motility and cell invasion in Toxoplasma gondii. Long S, Anthony B, Drewry LL, Sibley LD 10.1038/s41467-017-02341-2