PF3D7_0513200

Genome location: Pf3D7_05_v3:559,099..569,049(+)

Genome classification: Core

Function and Localization

Product Description: CPSF domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0031499	TRAMP complex
Component	GO:0005730	nucleolus
Function	GO:0004652	polynucleotide adenylyltransferase activity
Process	GO:0071044	histone mRNA catabolic process
Process	GO:0071050	sno(s)RNA polyadenylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.97	0.57
Trophozoite	expressed	1.32	0.37
Schizont	expressed	0.80	0.57
Gametocyte	possibly expressed	1.18	0.43

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0513200

Resistome Missense Mutations: D1027Y

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.081 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1112900)

Relative Growth Rate: 0.02 ± 0.05
Confidence: 7.34

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532434

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	40	99	55	162
disruptive	140	317	174	444
missense	81	227	145	348

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	62	204	100	183
disruptive	252	678	337	703
missense	125	488	264	459

PlasmoDB Total SNPs: 540

Non-coding: 188 | Synonymous: 172 | Nonsynonymous: 178 | Stop Codon: 2

Protein Information

Protein Length: 2763 | Molecular Weight (kDa): 332.134

UniProt ID(s): Q8I3X5

PDB ID(s): None

Isoelectric Point: 9.56

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004871	Cleavage/polyadenylation specificity factor, A subunit, C-terminal
PFam	PF03178	Cleavage/polyadenylation specificity factor, A subunit, C-terminal
Superfamily	N/A	N/A