Product Description: GTP-binding protein YihA1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0019001 | guanyl nucleotide binding |
| Function | GO:0043022 | ribosome binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.06 | 0.96 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.10 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0513400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -2.922 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1306100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4D6
"Best" AlphaFill ligand hit: PGR (r-1,2-propanediol, Local RMSD=0.10) with 7SZS (Global RMSD=2.19)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101142
Most Similar Human Ortholog: C9J0K3
TM-align score: 0.91 | RMSD: 1.72
Seq Identity: 0.26 | Length: 134 / 286
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000163607 | GTP binding protein 8 (putative) |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 8 | 5 | 21 |
| disruptive | 4 | 6 | 8 | 21 |
| missense | 4 | 6 | 8 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 30 | 11 | 18 |
| disruptive | 5 | 21 | 22 | 57 |
| missense | 5 | 19 | 20 | 40 |
PlasmoDB Total SNPs: 153
Non-coding: 135 | Synonymous: 14 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 286 | Molecular Weight (kDa): 33.29
UniProt ID(s): C0H4D6
PDB ID(s): None
Isoelectric Point: 10.14
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006073 | GTP binding domain |
| InterPro | IPR019987 | GTP-binding protein, ribosome biogenesis, YsxC |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR030393 | EngB-type guanine nucleotide-binding (G) domain |
| PFam | PF01926 | GTP binding domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 32057832 | YihA GTPases localize to the apicoplast and mitochondrion of the malaria parasiteand interact with LSU of organellar ribosomes. | Gupta A, Gupta K, Habib S | 10.1016/j.molbiopara.2020.111265 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |