Product Description: mitochondrial import inner membrane translocase subunit TIM16, putative
SignalP Peptide: MLPFRPLSQFVFQFLIITSTALG
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005744 | TIM23 mitochondrial import inner membrane translocase complex |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0030150 | protein import into mitochondrial matrix |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.10 | 0.95 |
| Trophozoite | not expressed | 0.21 | 0.87 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | not expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0513500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.342 | MFS: -3.364 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1113200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3X2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102816
Most Similar Human Ortholog: I3L3T0
TM-align score: 0.47 | RMSD: 2.42
Seq Identity: 0.35 | Length: 65 / 124
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000217930 | presequence translocase associated motor 16 |
| ENSG00000282228 | presequence translocase associated motor 16 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 7 | 2 | 8 |
| disruptive | 0 | 2 | 3 | 5 |
| missense | 0 | 2 | 3 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 13 | 3 | 12 |
| disruptive | 1 | 9 | 8 | 28 |
| missense | 0 | 6 | 5 | 17 |
PlasmoDB Total SNPs: 25
Non-coding: 20 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 124 | Molecular Weight (kDa): 14.606
UniProt ID(s): Q8I3X2
PDB ID(s): None
Isoelectric Point: 10.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005341 | Mitochondrial import inner membrane translocase subunit Tim16 |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |