Product Description: deoxyribodipyrimidine photo-lyase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 4.1.99.3 (Deoxyribodipyrimidine photo-lyase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003904 | deoxyribodipyrimidine photo-lyase activity |
| Process | GO:0006281 | DNA repair |
| Process | GO:0000719 | photoreactive repair |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.23 | 0.89 |
| Trophozoite | expressed | 1.39 | 0.35 |
| Schizont | expressed | 0.42 | 0.76 |
| Gametocyte | expressed | 1.67 | 0.27 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0513600
Resistome Missense Mutations: N226K
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.132 | MFS: -2.883 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1113300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1113300)
Modification: Disrupted | RMgm-2994
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I0W8
"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=0.88) with 8KCM (Global RMSD=3.48)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 4.1.99.3 | deoxyribodipyrimidine photo-lyase | glycerolFe(CN)63-clomifeneyeast DNAlornoxicamrupatadinePrednisoneazelastinefenofibrateferricyanideTriamcinolonedesloratidine... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 43 | 23 | 52 |
| disruptive | 73 | 118 | 55 | 121 |
| missense | 41 | 76 | 46 | 98 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 79 | 28 | 69 |
| disruptive | 114 | 233 | 105 | 203 |
| missense | 61 | 149 | 82 | 136 |
PlasmoDB Total SNPs: 325
Non-coding: 174 | Synonymous: 64 | Nonsynonymous: 87 | Stop Codon: 0
Protein Length: 1113 | Molecular Weight (kDa): 129.199
UniProt ID(s): Q8I0W8
PDB ID(s): None
Isoelectric Point: 9.59
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006050 | DNA photolyase, N-terminal |
| InterPro | IPR036134 | Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily |
| InterPro | IPR036155 | Cryptochrome/photolyase, N-terminal domain superfamily |
| PFam | PF00875 | DNA photolyase, N-terminal |
| Superfamily | SSF48173 | Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily |
| Superfamily | SSF52425 | Cryptochrome/photolyase, N-terminal domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |