About Gene List

PF3D7_0513700 (PSOP12)

Genome location: Pf3D7_05_v3:580,815..584,424(+)

Genome classification: Core

Function and Localization

Product Description: secreted ookinete protein, putative

SignalP Peptide: MTFISTFSQLILYTHVLLNICYG

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 0.99
Trophozoite not expressed 0.06 0.96
Schizont possibly expressed 0.02 0.99
Gametocyte expressed 0.86 0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0513700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -3.141 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1113400)

  • Relative Growth Rate: 1.02 ± 0.12
  • Confidence: 5.57

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1113400)

Modification: Disrupted | RMgm-2995

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8W5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215324

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 27 12 34
disruptive 15 48 30 59
missense 15 48 30 54

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 53 15 48
disruptive 30 99 51 144
missense 25 84 45 97

PlasmoDB Total SNPs: 218

Non-coding: 170 | Synonymous: 29 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 735 | Molecular Weight (kDa): 87.262

UniProt ID(s): A0A5K1K8W5

PDB ID(s): None

Isoelectric Point: 8.84

Protein Domain Annotations:

Source Family ID Description
InterPro IPR041396 Cysteine-rich protective antigen 6 bladed domain
PFam PF18638 Cysteine-rich protective antigen 6 bladed domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
25454088 The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarialtransmission blocking immunity both in vivo and in vitro. Sala KA, Nishiura H, ..., Blagborough AM 10.1016/j.vaccine.2014.11.038