PF3D7_0514200

Genome location: Pf3D7_05_v3:596,622..599,828(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.19	0.90
Trophozoite	possibly expressed	0.62	0.64
Schizont	expressed	0.50	0.69
Gametocyte	not expressed	0.68	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0514200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.981 | MFS: -2.411 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1113900)

Relative Growth Rate: 0.09 ± 0.09
Confidence: 6.24

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3W5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532639

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	46	29	49
disruptive	28	87	52	129
missense	20	72	43	100

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	91	32	54
disruptive	64	220	97	267
missense	36	163	70	153

PlasmoDB Total SNPs: 205

Non-coding: 85 | Synonymous: 76 | Nonsynonymous: 44 | Stop Codon: 0

Protein Information

Protein Length: 867 | Molecular Weight (kDa): 104.988

UniProt ID(s): Q8I3W5

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895