PF3D7_0514500

Genome location: Pf3D7_05_v3:604,633..606,347(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.01	1.00
Trophozoite	expressed	0.02	0.99
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.84	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0514500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.596 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1114100)

Modification: Tagged | RMgm-1144

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4D9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215326

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	15	9	22
disruptive	2	9	12	19
missense	2	9	12	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	24	16	33
disruptive	2	32	22	41
missense	2	26	21	32

PlasmoDB Total SNPs: 77

Non-coding: 66 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 215 | Molecular Weight (kDa): 25.233

UniProt ID(s): C0H4D9

PDB ID(s): None

Isoelectric Point: 8.19

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A