PF3D7_0514700

Genome location: Pf3D7_05_v3:610,089..614,771(+)

Genome classification: Core

Function and Localization

Product Description: MORN repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	not expressed	0.06	0.97
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.59	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0514700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.145 | #Insertions: 8

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1114300)

Relative Growth Rate: 0.85 ± 0.23
Confidence: 4.35

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1114300)

Modification: Disrupted | RMgm-3000

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3W1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533527

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	59	25	96
disruptive	87	198	101	313
missense	45	165	88	263

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	112	60	115
disruptive	153	467	247	484
missense	78	341	188	302

PlasmoDB Total SNPs: 222

Non-coding: 0 | Synonymous: 106 | Nonsynonymous: 113 | Stop Codon: 3

Protein Information

Protein Length: 1560 | Molecular Weight (kDa): 190.528

UniProt ID(s): Q8I3W1

PDB ID(s): None

Isoelectric Point: 10.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003409	MORN motif
PFam	PF02493	MORN motif
Superfamily	SSF82185	N/A