PF3D7_0514900

Genome location: Pf3D7_05_v3:618,369..620,372(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Component	GO:0005667	transcription regulator complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.37	0.82
Trophozoite	possibly expressed	0.46	0.72
Schizont	not expressed	0.21	0.86
Gametocyte	possibly expressed	0.42	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0514900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.054 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1114500)

Relative Growth Rate: 0.05 ± 0.09
Confidence: 6.28

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3V9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532385

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	16	9	33
disruptive	19	46	31	86
missense	16	40	29	77

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	38	20	34
disruptive	35	111	71	140
missense	25	86	58	94

PlasmoDB Total SNPs: 113

Non-coding: 90 | Synonymous: 12 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 438 | Molecular Weight (kDa): 51.9

UniProt ID(s): Q8I3V9

PDB ID(s): None

Isoelectric Point: 7.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
31728527	Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum.	Hoeijmakers WAM, Miao J, ..., Bartfai R	10.1093/nar/gkz1044
35984838	Mitochondrially targeted proximity biotinylation and proteomic analysis inPlasmodium falciparum.	Lamb IM, Rios KT, ..., Vaidya AB	10.1371/journal.pone.0273357