About Gene List

PF3D7_0515200

Genome location: Pf3D7_05_v3:627,289..627,961(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.99
Trophozoite not expressed 0.28 0.82
Schizont possibly expressed 0.17 0.89
Gametocyte not expressed 0.36 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0515200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.302 | MFS: -3.442 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3V6

"Best" AlphaFill ligand hit: TQP (, Local RMSD=0.62) with 5U21 (Global RMSD=14.46)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533615

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 1 3 5
disruptive 2 17 7 21
missense 2 16 7 19

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 9 8 8
disruptive 6 43 14 45
missense 4 37 11 26

PlasmoDB Total SNPs: 40

Non-coding: 34 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 142 | Molecular Weight (kDa): 17.074

UniProt ID(s): Q8I3V6

PDB ID(s): None

Isoelectric Point: 10.06

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16337634 Maurer's clefts: a novel multi-functional organelle in the cytoplasm ofPlasmodium falciparum-infected erythrocytes. Lanzer M, Wickert H, ..., Braun Breton C 10.1016/j.ijpara.2005.10.001