Product Description: conserved protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0070258 | inner membrane pellicle complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.11 | 0.94 |
Trophozoite | not expressed | 0.05 | 0.97 |
Schizont | expressed | 1.18 | 0.50 |
Gametocyte | expressed | 0.90 | 0.58 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0515400
Resistome Missense Mutations: C174S
Resistome Compounds with Missense Mutations: GNF-Pf-3600
Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.668 | #Insertions: 8
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1115000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1115000)
Modification: Disrupted | RMgm-3006
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4E0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 14 | 13 | 37 |
disruptive | 29 | 77 | 32 | 90 |
missense | 14 | 51 | 30 | 74 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 6 | 30 | 27 | 51 |
disruptive | 47 | 152 | 75 | 166 |
missense | 25 | 104 | 59 | 116 |
PlasmoDB Total SNPs: 222
Non-coding: 157 | Synonymous: 30 | Nonsynonymous: 35 | Stop Codon: 0
Protein Length: 761 | Molecular Weight (kDa): 89.968
UniProt ID(s): C0H4E0
PDB ID(s): None
Isoelectric Point: 9.32
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
34607461 | Revisiting the Role of Toxoplasma gondii ERK7 in the Maintenance and Stability ofthe Apical Complex. | Dos Santos Pacheco N, Tosetti N, ..., Soldati-Favre D | 10.1128/mBio.02057-21 |