About Gene List

PF3D7_0515400

Genome location: Pf3D7_05_v3:636,591..640,519(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.11 0.94
Trophozoite not expressed 0.05 0.97
Schizont expressed 1.18 0.50
Gametocyte expressed 0.90 0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0515400

Resistome Missense Mutations: C174S

Resistome Compounds with Missense Mutations: GNF-Pf-3600

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.668 | #Insertions: 8

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1115000)

  • Relative Growth Rate: 0.93 ± 0.18
  • Confidence: 4.82

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1115000)

Modification: Disrupted | RMgm-3006

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4E0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145485

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 14 13 37
disruptive 29 77 32 90
missense 14 51 30 74

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 30 27 51
disruptive 47 152 75 166
missense 25 104 59 116

PlasmoDB Total SNPs: 222

Non-coding: 157 | Synonymous: 30 | Nonsynonymous: 35 | Stop Codon: 0

Protein Information

Protein Length: 761 | Molecular Weight (kDa): 89.968

UniProt ID(s): C0H4E0

PDB ID(s): None

Isoelectric Point: 9.32

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
34607461 Revisiting the Role of Toxoplasma gondii ERK7 in the Maintenance and Stability ofthe Apical Complex. Dos Santos Pacheco N, Tosetti N, ..., Soldati-Favre D 10.1128/mBio.02057-21