PF3D7_0515600 (GEP)

Genome location: Pf3D7_05_v3:646,042..652,163(+)

Genome classification: Core

Function and Localization

Product Description: gamete egress protein GEP, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0044310	osmiophilic body

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.06	0.96
Schizont	not expressed	0.09	0.95
Gametocyte	expressed	0.90	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0515600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.945 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1115200)

Relative Growth Rate: 0.97 ± 0.24
Confidence: 4.23

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1115200)

Modification: Disrupted | RMgm-4830

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3V2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533562

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	46	29	69
disruptive	30	99	62	205
missense	23	74	56	182

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	86	37	89
disruptive	46	243	113	274
missense	32	195	95	198

PlasmoDB Total SNPs: 310

Non-coding: 200 | Synonymous: 65 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 1250 | Molecular Weight (kDa): 146.737

UniProt ID(s): Q8I3V2

PDB ID(s): None

Isoelectric Point: 7.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR025605	OST-HTH/LOTUS domain
PFam	PF12872	OST-HTH/LOTUS domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
32352241	Plasmodium berghei Gamete Egress Protein is required for fertility of bothgenders.	Andreadaki M, Pace T, ..., Curra C	10.1002/mbo3.1038
38385354	Gastrodia elata polysaccharide alleviates Parkinson's disease via inhibitingapoptotic and inflammatory signaling pathways and modulating the gut microbiota	Gan QX, Peng MY, ..., Ma YT	10.1039/d3fo05169b