PF3D7_0515800

Genome location: Pf3D7_05_v3:657,947..659,643(-)

Genome classification: Core

Function and Localization

Product Description: BolA-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0515800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.165 | MFS: -3.944 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3V0

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103994

Most Similar Human Ortholog: Q9H3K6

TM-align score: 0.90 | RMSD: 1.48

Seq Identity: 0.38 | Length: 84 / 84

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 109

Non-coding: 105 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 84 | Molecular Weight (kDa): 9.598

UniProt ID(s): Q8I3V0

PDB ID(s): 2KDN

Isoelectric Point: 7.7

Protein Domain Annotations: