PF3D7_0516000

Genome location: Pf3D7_05_v3:662,435..667,113(+)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.96
Trophozoite	expressed	0.42	0.77
Schizont	possibly expressed	0.18	0.88
Gametocyte	expressed	0.44	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0516000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.091 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3U8

"Best" AlphaFill ligand hit: DGT (2'-deoxyguanosine-5'-triphosphate, Local RMSD=0.54) with 6BRH (Global RMSD=18.41)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156433

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	39	32	51
disruptive	19	102	48	128
missense	15	89	46	122

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	77	45	68
disruptive	38	194	116	226
missense	26	164	102	166

PlasmoDB Total SNPs: 245

Non-coding: 143 | Synonymous: 46 | Nonsynonymous: 55 | Stop Codon: 1

Protein Information

Protein Length: 1084 | Molecular Weight (kDa): 129.137

UniProt ID(s): Q8I3U8

PDB ID(s): None

Isoelectric Point: 8.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013584	RAP domain
PFam	PF08373	RAP domain
Superfamily	N/A	N/A