About Gene List

PF3D7_0516400 (PhLP1)

Genome location: Pf3D7_05_v3:680,968..682,644(-)

Genome classification: Core

Function and Localization

Product Description: phosducin-like protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.05 0.97
Trophozoite expressed 0.26 0.83
Schizont expressed 0.30 0.79
Gametocyte expressed 0.40 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0516400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.151 | MFS: -2.827 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3U4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102481

Most Similar Human Ortholog: C9JST4

TM-align score: 0.74 | RMSD: 2.32

Seq Identity: 0.24 | Length: 80 / 335

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000115539 phosducin like 3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 10 17 18
disruptive 10 41 13 38
missense 6 28 12 31

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 24 15 23
disruptive 27 59 35 90
missense 15 45 32 62

PlasmoDB Total SNPs: 103

Non-coding: 64 | Synonymous: 22 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 335 | Molecular Weight (kDa): 39.798

UniProt ID(s): Q8I3U4

PDB ID(s): None

Isoelectric Point: 5.35

Protein Domain Annotations:

Source Family ID Description
InterPro IPR024253 Phosducin, thioredoxin-like domain
InterPro IPR036249 Thioredoxin-like superfamily
PFam PF02114 Phosducin, thioredoxin-like domain
Superfamily SSF52833 Thioredoxin-like superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
22995278 The evolution and putative function of phosducin-like proteins in the malariaparasite Plasmodium Putonti C, Quach B, Kooistra RL, Kanzok SM 10.1016/j.meegid.2012.08.023