Product Description: major facilitator superfamily domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 10
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Function | GO:0022857 | transmembrane transporter activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.01 | 1.00 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0516500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.87 | MFS: 1.215 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_1231300)
Modification: Disrupted | RMgm-4337
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4E1
"Best" AlphaFill ligand hit: ASD (4-androstene-3-17-dione, Local RMSD=0.02) with 3EQM (Global RMSD=20.09)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_108357
Most Similar Human Ortholog: Q96BI1
TM-align score: 0.86 | RMSD: 2.68
Seq Identity: 0.22 | Length: 395 / 442
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000110628 | solute carrier family 22 member 18 |
| ENSG00000276130 | solute carrier family 22 member 18 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 18 | 10 | 40 |
| disruptive | 1 | 16 | 12 | 43 |
| missense | 1 | 16 | 12 | 37 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 43 | 24 | 41 |
| disruptive | 5 | 48 | 34 | 76 |
| missense | 3 | 37 | 25 | 58 |
PlasmoDB Total SNPs: 101
Non-coding: 93 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 442 | Molecular Weight (kDa): 49.073
UniProt ID(s): C0H4E1
PDB ID(s): None
Isoelectric Point: 8.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001958 | Tetracycline resistance protein TetA/multidrug resistance protein MdtG |
| InterPro | IPR011701 | Major facilitator superfamily |
| InterPro | IPR036259 | MFS transporter superfamily |
| PFam | PF07690 | Major facilitator superfamily |
| Superfamily | SSF103473 | MFS transporter superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 31810592 | Investigation of mechanisms of toxicity and exclusion by transporters of thepreservatives triclosan and propylparaben using batteries of Schizosaccharomycespombe strains | Alvarez-Herrera C, Maisanaba S, Repetto G | 10.1016/j.envres.2019.108983 |
| 38408667 | A strategy for the investigation of toxic mechanisms and protection by effluxpumps using Schizosaccharomyces pombe strains: Application to rotenone | Alvarez-Herrera C, Maisanaba S, ..., Repetto G | 10.1016/j.scitotenv.2024.171253 |