Product Description: sporozoite surface antigen MB2
SignalP Peptide: MFLIWRLYKTLFLILYIIILQEYVCHS
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Component | GO:0005886 | plasma membrane |
| Component | GO:0020003 | symbiont-containing vacuole |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.26 | 0.87 |
| Trophozoite | expressed | 0.66 | 0.63 |
| Schizont | expressed | 0.56 | 0.68 |
| Gametocyte | possibly expressed | 0.52 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0516600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.128 | MFS: -3.064 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1231400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1231400)
Modification: Disrupted | RMgm-3323
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3U2
"Best" AlphaFill ligand hit: 5GP (guanosine-5'-monophosphate, Local RMSD=0.26) with 4AC9 (Global RMSD=3.73)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100987
Most Similar Human Ortholog: C9JIY5
TM-align score: 0.87 | RMSD: 0.33
Seq Identity: 0.12 | Length: 25 / 1610
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000085760 | mitochondrial translational initiation factor 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 45 | 37 | 89 |
| disruptive | 89 | 170 | 90 | 279 |
| missense | 51 | 137 | 72 | 232 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 25 | 100 | 58 | 105 |
| disruptive | 128 | 323 | 191 | 344 |
| missense | 75 | 242 | 162 | 271 |
PlasmoDB Total SNPs: 438
Non-coding: 249 | Synonymous: 113 | Nonsynonymous: 76 | Stop Codon: 0
Protein Length: 1610 | Molecular Weight (kDa): 187.039
UniProt ID(s): Q8I3U2, Q8WP98, Q8WR58, Q963G3, Q963G4, Q963G5, Q963G7, Q963G8, Q963G9
PDB ID(s): None
Isoelectric Point: 8.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000795 | Transcription factor, GTP-binding domain |
| InterPro | IPR005225 | Small GTP-binding protein domain |
| InterPro | IPR009000 | Translation protein, beta-barrel domain superfamily |
| InterPro | IPR011049 | Serralysin-like metalloprotease, C-terminal |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| InterPro | IPR015760 | Translation initiation factor IF- 2 |
| InterPro | IPR022967 | RNA-binding domain, S1 |
| InterPro | IPR023115 | Translation initiation factor IF- 2, domain 3 |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036925 | Translation initiation factor IF-2, domain 3 superfamily |
| PFam | PF00009 | Transcription factor, GTP-binding domain |
| PFam | PF11987 | Translation initiation factor IF- 2, domain 3 |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| Superfamily | SSF50447 | Translation protein, beta-barrel domain superfamily |
| Superfamily | SSF51120 | Serralysin-like metalloprotease, C-terminal |
| Superfamily | SSF52156 | Translation initiation factor IF-2, domain 3 superfamily |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11371568 | Stage-dependent localization of a novel gene product of the malaria parasite,Plasmodium falciparum. | Nguyen TV, Fujioka H, ..., James AA | 10.1074/jbc.M103375200 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 25689481 | Targeting and function of proteins mediating translation initiation in organellesof Plasmodium falciparum. | Haider A, Allen SM, ..., Habib S | 10.1111/mmi.12972 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |