Product Description: 60S ribosomal protein L12, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Component | GO:0005840 | ribosome |
| Function | GO:0070180 | large ribosomal subunit rRNA binding |
| Function | GO:0019843 | rRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000027 | ribosomal large subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.44 | 0.43 |
| Trophozoite | expressed | 1.83 | 0.24 |
| Schizont | expressed | 0.33 | 0.81 |
| Gametocyte | expressed | 0.68 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0517000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.128 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1231800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3T8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100843
Most Similar Human Ortholog: P30050
TM-align score: 0.98 | RMSD: 0.76
Seq Identity: 0.61 | Length: 165 / 165
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000197958 | ribosomal protein L12 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 164
Non-coding: 161 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 165 | Molecular Weight (kDa): 18.112
UniProt ID(s): Q8I3T8
PDB ID(s): None
Isoelectric Point: 10.21
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000911 | Ribosomal protein L11/L12 |
| InterPro | IPR020783 | Ribosomal protein L11, C-terminal |
| InterPro | IPR020784 | Ribosomal protein L11, N-terminal |
| InterPro | IPR020785 | Ribosomal protein L11, conserved site |
| InterPro | IPR036769 | Ribosomal protein L11, C-terminal domain superfamily |
| InterPro | IPR036796 | Ribosomal protein L11/L12, N-terminal domain superfamily |
| PFam | PF00298 | Ribosomal protein L11, C-terminal |
| PFam | PF03946 | Ribosomal protein L11, N-terminal |
| Superfamily | SSF46906 | Ribosomal protein L11, C-terminal domain superfamily |
| Superfamily | SSF54747 | Ribosomal protein L11/L12, N-terminal domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |