About Gene List

PF3D7_0517100

Genome location: Pf3D7_05_v3:717,799..719,939(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.53 0.74
Trophozoite possibly expressed 0.34 0.80
Schizont possibly expressed 0.09 0.95
Gametocyte not expressed 0.27 0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0517100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -3.189 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1231900)

  • Relative Growth Rate: 0.06 ± 0.07
  • Confidence: 6.78

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4E2

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=5.28) with 4DKJ (Global RMSD=11.96)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532340

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 19 9 25
disruptive 5 42 19 72
missense 5 40 18 66

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 33 23 27
disruptive 15 94 54 109
missense 10 82 46 81

PlasmoDB Total SNPs: 98

Non-coding: 69 | Synonymous: 18 | Nonsynonymous: 10 | Stop Codon: 1

Protein Information

Protein Length: 476 | Molecular Weight (kDa): 57.984

UniProt ID(s): C0H4E2

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895