PF3D7_0517200

Genome location: Pf3D7_05_v3:720,614..722,849(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0033018	sarcoplasmic reticulum lumen
Function	GO:0005509	calcium ion binding
Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.78	0.64
Trophozoite	possibly expressed	0.19	0.89
Schizont	expressed	0.11	0.93
Gametocyte	expressed	0.30	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0517200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.99 | MFS: -2.667 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1232000)

Relative Growth Rate: 1.08 ± 0.10
Confidence: 5.92

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1232000)

Modification: Disrupted | RMgm-3328

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3T6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532838

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	41	20	48
disruptive	74	123	68	130
missense	35	76	50	88

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	76	22	51
disruptive	125	205	91	158
missense	54	137	73	106

PlasmoDB Total SNPs: 138

Non-coding: 18 | Synonymous: 58 | Nonsynonymous: 62 | Stop Codon: 0

Protein Information

Protein Length: 632 | Molecular Weight (kDa): 75.549

UniProt ID(s): Q8I3T6

PDB ID(s): None

Isoelectric Point: 8.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001393	Calsequestrin
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily