Product Description: serine/arginine-rich splicing factor 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0016607 | nuclear speck |
| Component | GO:0005634 | nucleus |
| Component | GO:0005681 | spliceosomal complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0106153 | phosphorylated histone binding |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0006974 | cellular response to DNA damage stimulus |
| Process | GO:0045292 | mRNA cis splicing, via spliceosome |
| Process | GO:0006397 | mRNA processing |
| Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| Process | GO:0048024 | regulation of mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.97 | 0.56 |
| Trophozoite | expressed | 0.56 | 0.67 |
| Schizont | expressed | 0.27 | 0.82 |
| Gametocyte | expressed | 0.35 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0517300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.822 | MFS: -2.528 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3T5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102665
Most Similar Human Ortholog: J3QQV5
TM-align score: 0.72 | RMSD: 1.25
Seq Identity: 0.50 | Length: 52 / 298
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000111786 | serine and arginine rich splicing factor 9 |
| ENSG00000136450 | serine and arginine rich splicing factor 1 |
| ENSG00000266086 | novel transcript |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 237
Non-coding: 237 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 298 | Molecular Weight (kDa): 34.561
UniProt ID(s): Q8I3T5
Isoelectric Point: 11.18
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 22885299 | A novel Plasmodium falciparum SR protein is an alternative splicing factorrequired for the parasites' proliferation in human erythrocytes. | Eshar S, Allemand E, ..., Dzikowski R | 10.1093/nar/gks735 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25807998 | PfSR1 controls alternative splicing and steady-state RNA levels in Plasmodiumfalciparum through preferential recognition of specific RNA motifs. | Eshar S, Altenhofen L, ..., Dzikowski R | 10.1111/mmi.13007 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 30500338 | The N-terminal RNA Recognition Motif of PfSR1 Confers Semi-specificity forPyrimidines during RNA Recognition. | Ganguly AK, Verma G, Bhavesh NS | 10.1016/j.jmb.2018.11.020 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 34291805 | An S R protein is essential for activating D NA repair in malaria parasites | Goyal M, Singh BK, ..., Dzikowski R | 10.1242/jcs.258572 |
| 38075902 | The splicing factor SR2 is an important virulence factor of Toxoplasma gondii | Wu XJ, Gao J, ..., Zhu XQ | 10.3389/fmicb.2023.1302512 |