PF3D7_0517500

Genome location: Pf3D7_05_v3:735,386..738,469(-)

Genome classification: Core

Function and Localization

Product Description: UTP--glucose-1-phosphate uridylyltransferase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.7.7.9 (UTP--glucose-1-phosphate uridylyltransferase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity
Process	GO:0006048	UDP-N-acetylglucosamine biosynthetic process
Process	GO:0009226	nucleotide-sugar biosynthetic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.15	0.93
Trophozoite	possibly expressed	0.07	0.96
Schizont	possibly expressed	0.05	0.97
Gametocyte	expressed	0.79	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0517500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.555 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1232300)

Relative Growth Rate: 0.98 ± 0.10
Confidence: 6.00

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1232300)

Modification: Disrupted | RMgm-4613

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4E3

"Best" AlphaFill ligand hit: UTP (uridine 5'-triphosphate, Local RMSD=0.46) with 3OH0 (Global RMSD=4.08)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.7.7.9	UTP-glucose-1-phosphate uridylyltransferase	ATPADPUDPGTPCTPUTPNAD+NADP+MgUTPsucroseMgUTP2-Abacavir...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109569

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	24	20	51
disruptive	27	49	43	91
missense	14	38	38	67

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	64	38	54
disruptive	44	126	60	143
missense	20	86	49	108

PlasmoDB Total SNPs: 164

Non-coding: 86 | Synonymous: 48 | Nonsynonymous: 28 | Stop Codon: 2

Protein Information

Protein Length: 837 | Molecular Weight (kDa): 98.468

UniProt ID(s): C0H4E3

PDB ID(s): None

Isoelectric Point: 9.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002618	UDPGP family
InterPro	IPR029044	Nucleotide-diphospho-sugar transferases
InterPro	IPR039741	UDP-sugar pyrophosphorylase
PFam	PF01704	UDPGP family
Superfamily	SSF53448	Nucleotide-diphospho-sugar transferases