Product Description: F-actin-capping protein subunit beta, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0008290 | F-actin capping protein complex |
| Component | GO:0044310 | osmiophilic body |
| Function | GO:0051015 | actin filament binding |
| Process | GO:0051693 | actin filament capping |
| Process | GO:0051016 | barbed-end actin filament capping |
| Process | GO:0000902 | cell morphogenesis |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | not expressed | 0.05 | 0.97 |
| Schizont | not expressed | 0.11 | 0.93 |
| Gametocyte | expressed | 0.58 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0517600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.154 | #Insertions: 3
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1232400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1232400)
Modification: Disrupted | RMgm-3331
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3T2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103032
Most Similar Human Ortholog: B1AK87
TM-align score: 0.91 | RMSD: 1.84
Seq Identity: 0.32 | Length: 238 / 292
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000077549 | capping actin protein of muscle Z-line subunit beta |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 9 | 8 | 17 |
| disruptive | 5 | 12 | 12 | 32 |
| missense | 5 | 12 | 12 | 30 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 25 | 11 | 16 |
| disruptive | 7 | 40 | 30 | 73 |
| missense | 5 | 33 | 27 | 47 |
PlasmoDB Total SNPs: 163
Non-coding: 140 | Synonymous: 17 | Nonsynonymous: 5 | Stop Codon: 1
Protein Length: 292 | Molecular Weight (kDa): 34.758
UniProt ID(s): Q8I3T2
PDB ID(s): None
Isoelectric Point: 8.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001698 | F-actin-capping protein subunit beta |
| InterPro | IPR037282 | F-actin-capping protein subunit alpha/beta |
| PFam | PF01115 | F-actin-capping protein subunit beta |
| Superfamily | SSF90096 | F-actin-capping protein subunit alpha/beta |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 19682250 | Vital role for the Plasmodium actin capping protein (CP) beta-subunit in motilityof malaria sporozoites. | Ganter M, Schuler H, Matuschewski K | 10.1111/j.1365-2958.2009.06828.x |
| 27432909 | Comparative Proteomics and Functional Analysis Reveal a Role of Plasmodiumfalciparum Osmiophilic Bodies in Malaria Parasite Transmission. | Suarez-Cortes P, Sharma V, ..., Alano P | 10.1074/mcp.M116.060681 |