Product Description: eukaryotic translation initiation factor 3 subunit B, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Component | GO:0005634 | nucleus |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.02 | 0.54 |
| Trophozoite | expressed | 1.03 | 0.48 |
| Schizont | expressed | 0.19 | 0.88 |
| Gametocyte | expressed | 0.75 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0517700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.147 | MFS: -2.861 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1232500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3T1
"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=1.57) with 4GM9 (Global RMSD=4.69)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101924
Most Similar Human Ortholog: C9JQN7
TM-align score: 0.81 | RMSD: 2.84
Seq Identity: 0.31 | Length: 143 / 716
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000106263 | eukaryotic translation initiation factor 3 subunit B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 33 | 17 | 48 |
| disruptive | 0 | 9 | 8 | 16 |
| missense | 0 | 9 | 7 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 67 | 25 | 57 |
| disruptive | 4 | 30 | 21 | 63 |
| missense | 1 | 21 | 15 | 42 |
PlasmoDB Total SNPs: 86
Non-coding: 74 | Synonymous: 11 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 716 | Molecular Weight (kDa): 84.057
UniProt ID(s): Q8I3T1
PDB ID(s): None
Isoelectric Point: 8.21
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR011400 | Eukaryotic translation initiation factor 3 subunit B |
| InterPro | IPR013979 | Translation initiation factor, beta propellor-like domain |
| InterPro | IPR034363 | eIF3B, RNA recognition motif |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| PFam | PF08662 | Translation initiation factor, beta propellor-like domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| Superfamily | SSF69322 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |