Product Description: apicortin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0009986 | cell surface |
| Function | GO:0008017 | microtubule binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0032273 | positive regulation of protein polymerization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.00 | 1.00 |
| Trophozoite | not expressed | 0.01 | 1.00 |
| Schizont | possibly expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.63 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0517800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.237 | MFS: -2.461 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4E4
"Best" AlphaFill ligand hit: 4NC (4-nitrocatechol, Local RMSD=0.09) with 5PHD (Global RMSD=21.18)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O94811 | Tubulin polymerization-promoting protein | Homo sapiens | OrthoDB | Boronic acid, trans-6Boronic acid, trans-6combretastatin A-4, (CSA4)Boronic acid, trans-6... |
Protein Length: 238 | Molecular Weight (kDa): 27.923
UniProt ID(s): C0H4E4
PDB ID(s): None
Isoelectric Point: 10.05
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008907 | P25-alpha |
| InterPro | IPR011057 | Mss4-like superfamily |
| InterPro | IPR036572 | Doublecortin domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF51316 | Mss4-like superfamily |
| Superfamily | SSF89837 | Doublecortin domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 10 | 7 | 14 |
| disruptive | 2 | 25 | 18 | 35 |
| missense | 2 | 24 | 18 | 35 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 21 | 16 | 23 |
| disruptive | 7 | 47 | 22 | 48 |
| missense | 5 | 44 | 19 | 37 |
PlasmoDB Total SNPs: 31
Non-coding: 17 | Synonymous: 6 | Nonsynonymous: 8 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 32111164 | A doublecortin-domain protein of Toxoplasma and its orthologues bind to andmodify the structure and organization of tubulin polymers. | Leung JM, Nagayasu E, ..., Hu K | 10.1186/s12860-020-0249-5 |
| 32493727 | Targeted repression of Plasmodium apicortin by host micro RNA impairs malariaparasite growth and invasion | Chakrabarti M, Garg S, ..., Singh S | 10.1242/dmm.042820 |
| 33633135 | Interaction of Plasmodium falciparum apicortin with alpha- and beta-tubulin is criticalfor parasite growth and survival. | Chakrabarti M, Joshi N, ..., Singh S | 10.1038/s41598-021-83513-5 |