About Gene List

PF3D7_0517900

Genome location: Pf3D7_05_v3:747,364..749,746(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000781 chromosome, telomeric region
Function GO:0008270 zinc ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.08 0.96
Trophozoite possibly expressed 0.25 0.85
Schizont expressed 0.73 0.61
Gametocyte expressed 0.65 0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0517900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.146 | MFS: -2.923 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1304300)

  • Relative Growth Rate: 0.13 ± 0.08
  • Confidence: 6.50

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4E5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105580

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 19 19 44
disruptive 3 21 20 68
missense 3 21 18 66

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 54 22 40
disruptive 8 64 56 112
missense 4 55 50 90

PlasmoDB Total SNPs: 81

Non-coding: 57 | Synonymous: 19 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 560 | Molecular Weight (kDa): 65.058

UniProt ID(s): C0H4E5

PDB ID(s): None

Isoelectric Point: 6.57

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000315 B-box-type zinc finger
PFam PF00643 B-box-type zinc finger
Superfamily SSF56399 N/A
Superfamily SSF57845

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
28376558 Pf AP2Tel, harbouring a non-canonical D NA-binding A P2 domain, binds to Plasmodiumfalciparum telomeres Sierra-Miranda M, Vembar SS, ..., Hernandez-Rivas R 10.1111/cmi.12742